Iowa State defeated Kansas 68-53 Saturday.
The Jayhawks had an early 3-2 lead but trailed the rest of the game. Iowa State would lead by as many as 19 points in the 2nd half.
Jalen Wilson scored 26 points to lead Kansas in scoring.
The Jayhawks are now 18-5 for the season and 6-4 in the Big 12.
Kansas hosts Texas Monday night.